Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.2
USERS' SCORE
Good
Based on 6 Reviews
8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
L-Carnitine (as L-Carnitine Tartrate)
500 mg
â€
Top Medical Research Studies
9
We explored the relationship between circulating L-carnitine levels and the risk of neuromyelitis optica spectrum disorders (NMOSD) using data from genetic studies.
Our findings indicate that higher levels of L-carnitine may protect against NMOSD, specifically in patients who are negative for aquaporin-4 antibodies. However, there's no causal effect on the seropositive type of NMOSD.
This suggests that while L-carnitine could be a potential biomarker and therapeutic target, its effectiveness may vary depending on the patient subtype.
Our findings indicate that higher levels of L-carnitine may protect against NMOSD, specifically in patients who are negative for aquaporin-4 antibodies. However, there's no causal effect on the seropositive type of NMOSD.
This suggests that while L-carnitine could be a potential biomarker and therapeutic target, its effectiveness may vary depending on the patient subtype.
Read More
8
l-carnitine shows modest benefits
This study looked at how l-carnitine might help prevent muscle wasting in patients with Pemphigus Vulgaris, an autoimmune disease treated with glucocorticoids.
We administered l-carnitine or a placebo to 44 participants over eight weeks while measuring their muscle metabolism markers.
While the results showed some positive changes in markers like IGF-1 and myostatin, there were no significant differences between the l-carnitine and placebo groups.
Ultimately, l-carnitine appears to benefit muscle metabolism and regeneration but may not be markedly more effective than placebo.
We administered l-carnitine or a placebo to 44 participants over eight weeks while measuring their muscle metabolism markers.
While the results showed some positive changes in markers like IGF-1 and myostatin, there were no significant differences between the l-carnitine and placebo groups.
Ultimately, l-carnitine appears to benefit muscle metabolism and regeneration but may not be markedly more effective than placebo.
Read More
8
ALC promotes remyelination, improves motor function
We explored how acetyl-L-carnitine (ALC) might aid recovery in a mouse model of multiple sclerosis, a debilitating autoimmune disorder. Using a controlled study with three groups, we assessed the effects of ALC on coordination and balance in mice subjected to cuprizone diet for 12 weeks.
Our findings showed that mice receiving ALC demonstrated improved motor skills and remyelination in the corpus callosum. ALC helped reduce harmful free radicals and boosted specific myelin-related genes, indicating its potential as a therapeutic antioxidant for myelin repair.
Our findings showed that mice receiving ALC demonstrated improved motor skills and remyelination in the corpus callosum. ALC helped reduce harmful free radicals and boosted specific myelin-related genes, indicating its potential as a therapeutic antioxidant for myelin repair.
Read More
Most Useful Reviews
7.5
Improved spermogram
3 people found this helpful
Fine! I ordered this for my husband in hopes of improving his spermogram activity. After four months, there have been improvements in the analyses. Excellent preparation!
Read More
7.5
Boosts workout stamina
2 people found this helpful
L-Carnitine is my workout's best friend. I love this product as it aids my stamina despite having asthma, and I experience less soreness after workouts. The Jarrow Brand is also reliable, unlike another brand that caused unpleasant sweating. Overall, it enhances my workout significantly.
Read More
9
Sea of energy
1 people found this helpful
Excellent! This drug provides a sea of energy. I recommend it and will order it for myself again.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.2
- All Researches
9
We explored the relationship between circulating L-carnitine levels and the risk of neuromyelitis optica spectrum disorders (NMOSD) using data from genetic studies.
Our findings indicate that higher levels of L-carnitine may protect against NMOSD, specifically in patients who are negative for aquaporin-4 antibodies. However, there's no causal effect on the seropositive type of NMOSD.
This suggests that while L-carnitine could be a potential biomarker and therapeutic target, its effectiveness may vary depending on the patient subtype.
Our findings indicate that higher levels of L-carnitine may protect against NMOSD, specifically in patients who are negative for aquaporin-4 antibodies. However, there's no causal effect on the seropositive type of NMOSD.
This suggests that while L-carnitine could be a potential biomarker and therapeutic target, its effectiveness may vary depending on the patient subtype.
Read More
9
3,3-Dimethyl-1-butanol's anti-inflammatory effects
We investigated the effects of 3,3-dimethyl-1-butanol (DMB) on collagen-induced arthritis (CIA), an autoimmune condition. Our experiments revealed that DMB significantly reduced arthritis severity by over 50%, regardless of its role in trimethylamine production, a compound linked to inflammation.
Surprisingly, DMB worked independently of the gut microbiome. We identified a new metabolite from DMB, 3,3-dimethyl-1-butyric acid (DMBut), which also showed positive effects against inflammation. Together, these findings suggest that DMB and its metabolites offer a new way to manage autoimmune arthritis through immune system modulation.
Surprisingly, DMB worked independently of the gut microbiome. We identified a new metabolite from DMB, 3,3-dimethyl-1-butyric acid (DMBut), which also showed positive effects against inflammation. Together, these findings suggest that DMB and its metabolites offer a new way to manage autoimmune arthritis through immune system modulation.
Read More
9
L-Carnitine aids in arthritis treatment
We explored the effects of combining L-carnitine and zinc with methotrexate (MTX) to address gastrointestinal toxicity during arthritis treatment. Conducted on Wistar rats, the study assessed various treatments for their ability to counteract MTX-related intestinal damage while enhancing anti-arthritic benefits.
We found that the combination of zinc and L-carnitine notably reduced oxidative stress and inflammation associated with MTX, activating protective signaling pathways. Overall, this approach shows promise in balancing effective arthritis management with reduced gastrointestinal side effects.
We found that the combination of zinc and L-carnitine notably reduced oxidative stress and inflammation associated with MTX, activating protective signaling pathways. Overall, this approach shows promise in balancing effective arthritis management with reduced gastrointestinal side effects.
Read More
9
We identified that L-carnitine levels play a role in immune checkpoint inhibitor (ICI) induced myasthenia gravis (MG), a serious immune-related side effect. Through comparative genomic analysis of a thymoma patient, we discovered a genetic variant linked to this condition. Remarkably, when this patient underwent ICI treatment again with L-carnitine pretreatment, they experienced a notable response without any MG symptoms returning. This finding offers a promising glimpse into personalized treatment strategies for managing adverse effects associated with cancer therapies.
Read More
8
l-carnitine shows modest benefits
This study looked at how l-carnitine might help prevent muscle wasting in patients with Pemphigus Vulgaris, an autoimmune disease treated with glucocorticoids.
We administered l-carnitine or a placebo to 44 participants over eight weeks while measuring their muscle metabolism markers.
While the results showed some positive changes in markers like IGF-1 and myostatin, there were no significant differences between the l-carnitine and placebo groups.
Ultimately, l-carnitine appears to benefit muscle metabolism and regeneration but may not be markedly more effective than placebo.
We administered l-carnitine or a placebo to 44 participants over eight weeks while measuring their muscle metabolism markers.
While the results showed some positive changes in markers like IGF-1 and myostatin, there were no significant differences between the l-carnitine and placebo groups.
Ultimately, l-carnitine appears to benefit muscle metabolism and regeneration but may not be markedly more effective than placebo.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved spermogram
3 people found this helpful
Fine! I ordered this for my husband in hopes of improving his spermogram activity. After four months, there have been improvements in the analyses. Excellent preparation!
Read More
7.5
Boosts workout stamina
2 people found this helpful
L-Carnitine is my workout's best friend. I love this product as it aids my stamina despite having asthma, and I experience less soreness after workouts. The Jarrow Brand is also reliable, unlike another brand that caused unpleasant sweating. Overall, it enhances my workout significantly.
Read More
9
Sea of energy
1 people found this helpful
Excellent! This drug provides a sea of energy. I recommend it and will order it for myself again.
Read More
9
Aids energy issues
This is a high-quality carnitine supplement that many in my family use with great results. I would highly recommend it, especially for those suffering from neurological disorders or energy issues, as it helps to derive energy from fats.
Read More
0
No noticeable effect
I expected much from L-Carnitine after reading about its importance for various bodily systems, but unfortunately, I did not feel any effect. There was no promised surge of strength or energy.
Read More
Frequently Asked Questions
7.5
Improved spermogram
3 people found this helpful
Fine! I ordered this for my husband in hopes of improving his spermogram activity. After four months, there have been improvements in the analyses. Excellent preparation!
0
No noticeable effect
I expected much from L-Carnitine after reading about its importance for various bodily systems, but unfortunately, I did not feel any effect. There was no promised surge of strength or energy.
7.5
Boosts workout stamina
2 people found this helpful
L-Carnitine is my workout's best friend. I love this product as it aids my stamina despite having asthma, and I experience less soreness after workouts. The Jarrow Brand is also reliable, unlike another brand that caused unpleasant sweating. Overall, it enhances my workout significantly.
9
Sea of energy
1 people found this helpful
Excellent! This drug provides a sea of energy. I recommend it and will order it for myself again.
9
Aids energy issues
This is a high-quality carnitine supplement that many in my family use with great results. I would highly recommend it, especially for those suffering from neurological disorders or energy issues, as it helps to derive energy from fats.
9
We explored the relationship between circulating L-carnitine levels and the risk of neuromyelitis optica spectrum disorders (NMOSD) using data from genetic studies.
Our findings indicate that higher levels of L-carnitine may protect against NMOSD, specifically in patients who are negative for aquaporin-4 antibodies. However, there's no causal effect on the seropositive type of NMOSD.
This suggests that while L-carnitine could be a potential biomarker and therapeutic target, its effectiveness may vary depending on the patient subtype.
Our findings indicate that higher levels of L-carnitine may protect against NMOSD, specifically in patients who are negative for aquaporin-4 antibodies. However, there's no causal effect on the seropositive type of NMOSD.
This suggests that while L-carnitine could be a potential biomarker and therapeutic target, its effectiveness may vary depending on the patient subtype.
9
We identified that L-carnitine levels play a role in immune checkpoint inhibitor (ICI) induced myasthenia gravis (MG), a serious immune-related side effect. Through comparative genomic analysis of a thymoma patient, we discovered a genetic variant linked to this condition. Remarkably, when this patient underwent ICI treatment again with L-carnitine pretreatment, they experienced a notable response without any MG symptoms returning. This finding offers a promising glimpse into personalized treatment strategies for managing adverse effects associated with cancer therapies.
8
ALC promotes remyelination, improves motor function
We explored how acetyl-L-carnitine (ALC) might aid recovery in a mouse model of multiple sclerosis, a debilitating autoimmune disorder. Using a controlled study with three groups, we assessed the effects of ALC on coordination and balance in mice subjected to cuprizone diet for 12 weeks.
Our findings showed that mice receiving ALC demonstrated improved motor skills and remyelination in the corpus callosum. ALC helped reduce harmful free radicals and boosted specific myelin-related genes, indicating its potential as a therapeutic antioxidant for myelin repair.
Our findings showed that mice receiving ALC demonstrated improved motor skills and remyelination in the corpus callosum. ALC helped reduce harmful free radicals and boosted specific myelin-related genes, indicating its potential as a therapeutic antioxidant for myelin repair.
References
- Hu W, Hu Y, Li J, Men Y, Xia J, et al. Effect of L-Carnitine Level on the Risk of Neuromyelitis Optica Spectrum Disorders: A Two-Sample Mendelian Randomization Study. Mol Neurobiol. 2025;62:5133. doi:10.1007/s12035-024-04607-5
- Fechtner S, Allen BE, Chriswell ME, Jubair WK, Robertson CE, et al. 3,3-Dimethyl-1-Butanol and its Metabolite 3,3-Dimethylbutyrate Ameliorate Collagen-induced Arthritis Independent of Choline Trimethylamine Lyase Activity. Inflammation. 2024. doi:10.1007/s10753-024-02126-y
- Katturajan R, Evan Prince S. Zinc and L-carnitine combination with or without methotrexate prevents intestinal toxicity during arthritis treatment via Nrf2/Sirt1/Foxo3 pathways: an In vivo and molecular docking approach. Inflammopharmacology. 2023;31:2599. doi:10.1007/s10787-023-01280-3
- Noormohammadi Z, Arghavani H, Javanbakht M, Daneshpazhooh M, Jalili M. l-carnitine downregulate the muscle wasting effect of glucocorticoids in pemphigus patient: A randomized double-blind placebo-controlled study. Physiol Rep. 2023;11:e15657. doi:10.14814/phy2.15657
- Zhang Q, Zhu Y, Lv C, Fang Y, Liao M, et al. AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2/K63-ubiquitination pathway. Immunology. 2023;169:412. doi:10.1111/imm.13638
- Teixeira CF, Azzolin VF, Rodrigues Dos Passos G, Turra BO, Alves AO, et al. A coffee enriched with guarana, selenium, and l-carnitine (GSC) has nutrigenomic effects on oxi-inflammatory markers of relapsing-remitting multiple sclerosis patients: A pilot study. Mult Scler Relat Disord. 2023;71:104515. doi:10.1016/j.msard.2023.104515
- Gao W, Wu L, Jin S, Li J, Liu X, et al. Rechallenge of immune checkpoint inhibitors in a case with adverse events inducing myasthenia gravis. J Immunother Cancer. 2022;10. doi:10.1136/jitc-2022-005970
- Gharighnia S, Omidi A, Ragerdi Kashani I, Sepand MR, Pour Beiranvand S. Ameliorative effects of acetyl-L-carnitine on corpus callosum and functional recovery in demyelinated mouse model. Int J Neurosci. 2024;134:409. doi:10.1080/00207454.2022.2107515
- Badreldeen A, El Razaky O, Erfan A, El-Bendary A, El Amrousy D. Comparative study of the efficacy of captopril, simvastatin, and L-carnitine as cardioprotective drugs in children with type 1 diabetes mellitus: a randomised controlled trial. Cardiol Young. 2021;31:1315. doi:10.1017/S1047951121000226
